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METHODS IN ENZYMOLOGY VOL-378: QUINOES AND QUINONE ENZYMES PART-A (hb)2004
Author: HELMUT SIES
ISBN: 0121827828
Year: 2004
Publisher: ELSEVIER INC. USA
Category: BIOCHEMISTRY
Edition: 1
Format: Hard Cover
Language: English
Pages: 421
Volume: 378
 ABOUT THE TITLE
Quinones are members of a class of aromatic compounds with two oxygen atoms bonded to the ring as carbonyl groups. This volume covers the role of quinines enzymes in cellular signalling and modulation of gene expression.
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 TABLE OF CONTENTS
Contributors to Volume 378
Preface
Volumes in Series
1 Investigation of Regulatory Mechanisms in Coenzyme Q Metabolism 3
2 Methods for Characterizing TPQ-Containing Proteins 17
3 Aldo-Keto Reductases and Formation of Polycyclic Aromatic Hydrocarbon o-Quinones 31
4 Redox Cycling of [beta]-Lapachone and Structural Analogues in Microsomal and Cytosol Liver Preparations 67
5 Quinone Chemistry and Melanogenesis 88
6 Quinoids Formed from Estrogens and Antiestrogens 110
7 Ubiquinone and Plastoquinone Metabolism in Plants 124
8 Extramitochondrial Reduction of Ubiquinone by Flavoenzymes 131
9 Tissue Bioavailability and Detection of Coenzyme Q 138
10 Coenzyme Q and Vitamin E Interactions 146
11 Preparation of Tritium-Labeled 3-Methyl-3-buten-1[[superscript 3]H]-yl Disphosphate ([superscript 3]H-Isopentenyl Diphosphate) 152
12 High-Performance Liquid Chromatography - EC Assay of Mitochondrial Coenzyme Q[subscript 9], Coenzyme Q[subscript 9]H[subscript 2], Coenzyme Q[subscript 10], Coenzyme Q[subscript 10]H[subscript 2], and Vitamin E with a Simplified On-Line Solid-Phase Extraction 156
13 Simultaneous Determination of Coenzyme Q[subscript 10], Cholesterol, and Major Cholesterylesters in Human Blood Plasma 162
14 Assay of Coenzyme Q[subscript 10] in Plasma by a Single Dilution Step 170
15 Quinone Oxidoreductases of the Plasma Membrane 179
16 Regulation of Ceramide Signaling by Plasma Membrane Coenzyme Q Reductases 200
17 Stabilization of Extracellular Ascorbate Mediated by Coenzyme Q Transmembrane Electron Transport 207
18 Regulation of Antioxidant Response Element-Dependent Induction of Detoxifying Enzyme Synthesis 221
19 Antioxidant Responsive Element Activation by Quinones: Antioxidant Responsive Element Target Genes, Role of PI3 Kinase in Activation 238
20 Signaling Effects of Menadione: From Tyrosine Phosphatase Inactivation to Connexin Phosphorylation 258
21 Unique Function of the Nrf2-Keap1 Pathway in the Inducible Expression of Antioxidant and Detoxifying Enzymes 273
22 Role of Protein Phosphorylation in the Regulation of NF-E2-Related Factor 2 Activity 286
23 Analysis of Transcription Factor Remodeling in Phase II Gene Expression with Curcumin 302
24 Quinones and Glutathione Metabolism 319
25 Doxorubicin Cardiotoxicity and the Control of Iron Metabolism: Quinone-Dependent and Independent Mechanisms 340
26 Oxidant-Induced Iron Signaling in Doxorubicin-Mediated Apoptosis 362
Author Index 383
Subject Index 411
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